REILLY ASSOCIATES
 WPAI References

Agarwal U, Mishra S, Xu J, Levin S, Gonzales J, Barnard ND. A Multicenter Randomized Controlled Trial of a Nutrition Intervention Program in a Multiethnic Adult Population in the Corporate Setting Reduces Depression and Anxiety and Improves Quality of Life: The GEICO Study. Am J Health Promot. 2014 Feb 13.

Allen-Ramey FC, Gupta S, Dibonaventura MD. Patient characteristics, treatment patterns, and health outcomes among COPD phenotypes. Int J Chron Obstruct Pulmon Dis. 2012;7:779-87.

American College of Allergy, Asthma and Immunology.  Instruments for measuring Quality of life and performance impairment in allergic rhinitis.  Ann Allergy Asthma Immunol 2001; 86(5): insert.

Andréasson E, Svensson K, Berggren F. The validity of the work productivity and activity impairment questionnaire for patients with asthma (WPAI-asthma): Results from a web-based study. Value in Health 2003;6(6):780

Andréasson E, Svensson K, Berggren F. The validity of the work productivity and activity impairment questionnaire for patients with asthma (WPAI-asthma): Results from a web-based study.Presented ISPOR 6th Annual European Congress, 9-11 November 2003, Barcelona, Spain.

Ariza-Ariza R, Hernández-Cruz B, Navarro-Compán V, Leyva Pardo C, Juanola X, Navarro-Sarabia F. A comparison of telephone and paper self-completed questionnaires of main patient-related outcome measures in patients with ankylosing spondylitis and psoriatic arthritis. Rheumatol Int. 2013 Jun 21.

Asami Y, Goren A, Okumura Y. Work productivity loss with depression, diagnosed and undiagnosed, among workers in an internet-based survey conducted in Japan. J Occup Environ Med. 2015 Jan;57(1):105-10.

Bae SC, Gun SC, Mok CC, Khandker R, Nab HW, Koenig AS, Vlahos B, Pedersen R,
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Bixquert M, Calleja J, Maldonado J, Ballesteros E, Vara S, Rico-Villademoros F.  Impact of nocturnal heartburn on quality of life, sleep and productivity: the Sinerge Study.  Gut 2004; 53(Suppl V1)A99.

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Bracco A, Reilly MC, McBurney C, Ambegaonkar B.  Burden of Irritable Bowel Syndrome with constipation on health care resource utilization, work productivity and activity impairment and quality of life.  Presented 13th World Congress of Gastroenterology,  Montreal, Canada September 10-14, 2005.

Brown M, Feagan B, Gerlier L, Schreiber S. Treatment with certolizumob pegol 400 mg improves work productivity and daily activities in patients with Crohn’s disease: PRECISE 2 data. Amer J Gastroent. 2006: 101 (s2). (Abstract)

Brown M, Feagan B, Gerlier L, Schreiber S. Treatment with certolizumob pegol 400 mg improves work productivity and daily activities in patients with Crohn’s disease: PRECISE 2 data.  Presentation at American College of Gastroenterology (ACG), 71st Annual Scientific Meeting, October 20-25 2006, Las Vegas, NV.

Brozek JL, Guyatt GH, Heels-Ansdell D, Degl'Innocenti A, Armstrong D, Fallone CA, Wiklund I, van Zanten SV, Chiba N, Barkun AN, Akl EA, Schünemann HJ. Specific HRQL instruments and symptom scores were more responsive than preference-based generic instruments in patients with GERD. J Clin Epidemiol. 2009;62(1):102-10. Epub 2008 Jul 10.

Bruley des Varannes S, Ducrotté P, Vallot T, Garofano A, Bardoulat I, Carrois F, Ricci L. Gastroesophageal reflux disease: Impact on work productivity and daily-life activities of daytime workers. A French cross-sectional study. Dig Liver Dis. 2012 Dec 10.

Bushmakin AG, Cappelleri JC, Taylor-Stokes G, Sayers J, Sadosky A, Carroll D, Gosden T, Emery P. Relationship between patient-reported disease severity and other clinical outcomes in osteoarthritis: a European perspective. J Med Econ. 2011 May 17. [Epub ahead of print]

Bushnell DM, Galani C, Martin ML, Ricci JF, Reilly MC, Patrick DL.Validation of EDC versions of IBS-QOL, EQ-5D and WPAI-IBS questionnaires.Value in Health 2005 (8):383.  (Presented ISPOR 10th Annual International Meeting, Washington DC, May 15-18, 2005.)

Bushnell DM, Reilly MC, Galani C, Martin ML, Ricci JF, , Patrick DL, McBurney C.  Validation of EDC versions of IBS-QOL, EQ-5D and WPAI-IBS questionnaires.   Value in Health. 2006; 9(2):98-105.

Bytzer P, Langkilde LK, Christensen E, Meineche-Schmidt V. Work productivity
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Calhoun WJ, Haselkorn T, Mink DR, Miller DP, Dorenbaum A, Zeiger RS. Clinical Burden and Predictors of Asthma Exacerbations in Patients on Guideline-based Steps 4-6 Asthma Therapy in the TENOR Cohort. J Allergy Clin Immunol Pract. 2014 Mar-Apr;2(2):193-200.

Calleja JL, Bixquert M, Maldonado J; for the SINERGE Study Group. Impact of Nocturnal Heartburn on Quality of Life, Sleep, and Productivity: The SINERGE Study. Dig Dis Sci. 2006 Jul 29; [Epub ahead of print] 

Cepeda MS, Sutton A, Weinstein R, Kim M. Effect of Tapentadol Extended Release on Productivity: Results From an Analysis Combining Evidence From Multiple Sources. Clin J Pain. 2011 Jun 3. [Epub ahead of print]

Chan B, Hales B, Shear N, Ho V, Lynde C, Poulin Y, Mittmann N. Work-related lost productivity and its economic impact on Canadian patients with moderate tosevere psoriasis. J Cutan Med Surg. 2009;13(4):192-7. 

Chaparro Del Moral R, Rillo OL, Casalla L, Morón CB, Citera G, Cocco JA, Correa Mde L, Buschiazzo E, Tamborenea N, Mysler E, Tate G, Baños A, Herscovich N. Work productivity in rheumatoid arthritis: relationship with clinical and radiological features. Arthritis. 2012;2012:137635.  Epub 2012 Dec 19.

Chirban JT, Jacobs RJ, Warren J, Prakash E, Sodomsky ME, Clarke JF, et al.  The 36-Item Short Form Health Survey (SF-36) and the Work Productivity and Activity Impairment (WPAI) Questionnaire in panic disorder.  Dis Manage Health Outcomes 1997; 1(3):154-164.

Chen H, Blanc PD, Chawla A, Hayden M, Bleeker ER, Lee JH.  Assessing productivity impairment in patients with severe or difficult to treat asthma: validation of the Work Productivity and Activity Impairment- Asthma questionnaire.  J Allergy Clin Immunol 2006; 117(2):S181

Chen H, Blanc PD, Hayden ML, Bleecker ER, Chawla A, Lee JH, TENOR Study Group.  Assessing productivity loss and activity impairment in severe or difficult-to-treat asthma. Value in Health (OnlineEarly Articles). doi:10.1111/j.1524-4733.2007.00229.x

Chey WD, Howden CW, Tack J, Ligozio G, Earnest DL. Long-Term Tegaserod Treatment for Dysmotility-like Functional Dyspepsia: Results of Two Identical 1-year Cohort Studies.  Dig Dis Sci. 2009 Dec 3. [Epub ahead of print] 

Ciconelli RM, Soarez PC, Kowalski CC, Ferraz MB.  The Brazilian Portuguese version of the Work Productivity and Activity Impairment: General Health (WPAI-GH) Questionnaire. Sao Paulo Med J. 2006;124(6):325-332. 

Cleeland CS, Mayer M, Dreyer NA, Yim YM, Yu E, Su Z, Mun Y, Sloan JA, Kaufman PA. Impact of symptom burden on work-related abilities in patients with locally recurrent or metastatic breast cancer: Results from a substudy of the VIRGO observational cohort study. Breast. 2014 Sep 2.

Cohen BL, Zoëga H, Shah SA, Leleiko N, Lidofsky S, Bright R, Flowers N, Law M, Moniz H, Merrick M, Sands BE. Fatigue is highly associated with poor health-related quality of life, disability and depression in newly-diagnosed patients with inflammatory bowel disease, independent of disease activity. Aliment Pharmacol Ther. 2014 Apr;39(8):811-22. 

Colamonic J, Formella A, Bradley W. Pseudobulbar Affect: Burden of Illness in the USA. Adv Ther. 2012 Aug 30.

Colombel JF, Rutgeerts PJ, Sandborn WJ, Yang M, Camez A, Pollack PF, Thakkar RB, Robinson AM, Chen N, Mulani PM, Chao J. Adalimumab Induces Deep Remission in Patients with Crohn's Disease. Clin Gastroenterol Hepatol. 2013 Jul 12. 

Courneya KS, Booth CM, Gill S, O’Brien P, Vardy J et al. The Colon Health and Life-Long Exercise Change trial: a randomized trial of the National Cancer Institute of Canada Clinical Trials Group.  Curr Oncol. 2008 December; 15(6): 271–278.

Coyle PK, Cohen BA, Leist T, Markowitz C, Oleen-Burkey M, Schwartz M, Tullman MJ, Zwibel H. Therapy optimization in multiple sclerosis: a prospective observational study of therapy compliance and outcomes. BMC Neurol. 2014 Mar 13;14(1):49. 

Coyne KS, LoCasale RJ, Datto CJ, Sexton CC, Yeomans K, Tack J. Opioid-induced constipation in patients with chronic noncancer pain in the USA, Canada, Germany, and the UK: descriptive analysis of baseline patient-reported outcomes and retrospective chart review. Clinicoecon Outcomes Res. 2014 May 23;6:269-81.

Coyne KS, Sexton CC, Irwin DE, Kopp ZS, Kelleher CJ, Milsom I.  The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study. BJU Int. 2008;101(11):1388-95.

Coyne KS, Sexton CC, Thompson CL, Clemens JQ, Chen CI, Bavendam T, Dmochowski 
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Crawford B, Okuda M, Leahy MJ.  The RQLQ AND WPAI-AS questionnaires are valid, reliable measures of QOL in Japanese pateints with seasonal allergic rhinits. Presented ISPOR First Asia-Pacific Conference, 1-3 September 2003, Kobe, Japan.

da Rocha Castelar Pinheiro G, Khandker RK, Sato R, Rose A, Piercy J. Impact of
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Dacosta Dibonaventura M, Gupta S, Cho M, Mrus J. The association of HIV/AIDS
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Dacosta Dibonaventura M, Paulose-Ram R, Su J, McDonald M, Zou KH, Wagner JS, Shah H. The Impact of COPD on Quality of Life, Productivity Loss, and Resource Use among the Elderly United States Workforce. COPD. 2012 Feb;9(1):46-57.

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Dean BB, Aguilar D, Barghout V, Kahler KH, Frech F, Groves D, Ofman JJ.  Impairment in work productivity and health-related qulaity of life in patients with IBS.  Amer J Man Care 2005 (11); S17-26.:

Dean B, Aguilar D, Shapiro C, Orr WC, Isserman JA, Calimlim B, Rippon GA. Impaired health status, daily functioning, and work productivity in adults with excessive sleepiness. J Occup Environ Med. 2010;52(2):144-9.

Dean BB, Calimlim BC, Sacco P, Aguilar D, Maykut R, Tinkelman D. Uncontrolled 
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Dean BB, Calimlim B, Aguilar D, Sacco P, Maykut R, Tinkelman D, impact of uncontrolled pediatric asthma on child and caregiver productivity. ISPOR 13th Annual International Meeting, Toronto, Ontario, Canada, May 3, 2008.

Dean BB, Crawley JA, Reeves JD, Aguilar D, Sullivan S.  The cost of gastroesophageal reflux disease: it's what you don't see that counts.  JMCM 2003; 7(2): 6-13.

Dean BB, Crawley JA, Schmitt CM, Wong J, Ofman JJ.  The burden of illness of gastro-oesophageal reflux disease: impact on work productivity.  Alimentary Pharmacology  & Therapeutics 2003:17 (10): 1309-1317.

Dean BB, Crawley JA, Schmitt CM., Ofman JJ.  The Impact of GERD Symptoms on Worker Productivity and Absenteeism.  Presented ACG Meeting 2001.

Dean BB, Crawley JA, Schmitt CM., Ofman JJ. The Association Between Worker Productivity and Quality of Life in GERD.  Pesented ACG Meeting 2001.

Demoly P, Annunziata K, Gubba E, Adamek L. Repeated cross-sectional survey of 
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Demoly P, Gueron B, Annunziata K, Adamek L, Walters RD. Update on asthma control in five European countries: results of a 2008 survey. Eur Respir Rev. 2010;19(116):150-7.

Despiégel N, Danchenko N, François C, Lensberg B, Drummond MF. The use and
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Dibonaventura MD, Andrews LM, Yadao AM, Kahler KH. The effect of gout on health-related quality of life, work productivity, resource use and clinical outcomes among patients with hypertension. Expert Rev Pharmacoecon Outcomes Res. 2012 Dec;12(6):821-9.

Dibonaventura MD, Cappelleri JC, Joshi AV. Association between Pain Severity
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Dibonaventura MD, Chandran A, Hsu MA, Bushmakin A. Burden of vasomotor
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Dibonaventura MD, Gupta S, McDonald M, Sadosky A, Pettitt D, Silverman S.
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Di Bonaventura MD, Gupta S, McDonald MM, Sadosky A. Evaluating the health and 
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Dibonaventura M, Link C, Pollack MF, Wagner JS, Williams SA. The Relationship 
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Dibonaventura MD, Paulose-Ram R, Su J, McDonald M, Zou KH, Wagner JS, Shah H. 
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Dibonaventura MD, Prior M, Prieto P, Fortea J. Burden of constipation-predominant irritable bowel syndrome (IBS-C) in France, Italy, and the United Kingdom. Clin Exp Gastroenterol. 2012;5:203-12. doi:10.2147/CEG.S35568. Epub 2012 Nov 8.

Dibonaventura M, Sun SX, Bolge SC, Wagner JS, Mody R. Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome. Curr Med Res Opin. 2011 Sep 28. [Epub ahead of print]

Dibonaventura MD, Wagner JS, Yuan Y, L'italien G, Langley P, Ray Kim W. The
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Ekesbo R, Sjöstedt S, Sörngård H. Effects of Structured Follow-Up and of More 
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El Khoury AC, Vietri J, Prajapati G. The Burden of Untreated Hepatitis C Virus
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Engsbro AL, Begtrup LM, Kjeldsen J, Larsen PV, de Muckadell OS, Jarbøl DE, Bytzer P. Patients Suspected of Irritable Bowel Syndrome-Cross-Sectional Study Exploring the Sensitivity of Rome III Criteria in Primary Care. Am J Gastroenterol. 2013 Feb 19. doi: 10.1038/ajg.2013.15. [Epub ahead of print]

Erickson SR, Guthrie S, Vanetten-Lee M, Himle J, Hoffman J, Santos SF, Janeck  AS, Zivin K, Abelson JL. Severity of anxiety and work-related outcomes of patients with anxiety disorders. Depress Anxiety. 2009 Oct 19. [Epub ahead of print] 

Erickson S, Guthrie S, Abelson J.  Health status and work-related outcomes of patients with anxiety disorders and depression.  Poster presentation, ISPOR 13th Annual International Meeting Toronto, Ontario, Canada, May 03, 2008.

Ettigi P, Meyerhoff AS, Chirban JT, Jacobs RJ, Wilson RR.  The quality of life and employment in panic disorder. J Nerv Ment Dis 1997; 185(6):368-72.

Evers KE, Castle PH, Prochaska JO, Prochaska JM. Examining relationships between multiple health risk behaviors, well-being, and productivity. Psychol Rep. 2014 Jun;114(3):843-53. 

Fairchild CJ, Meltzer EO, Roland PS, Wells D, Drake M, Wall GM.  Comprehensive report of the efficacy, safety, quality of life, and work impact of Olopatadine 0.6% and Olopatadine 0.4% treatment in patients with seasonal allergic rhinitis.
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Feagan BG, Reilly MC, Gerlier L, Brabant Y, Brown M, Schreiber S. Clinical trial: the effects of certolizumab pegol therapy on work productivity in patients with moderate-to-severe Crohn's disease in the PRECiSE 2 study. Aliment Pharmacol Ther. 2010 Mar 18. [Epub ahead of print]

Feagan BG, Sandborn WJ, Wolf DC, Coteur G, Purcaru O, Brabant Y, Rutgeerts PJ.
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Feagan B, Schreiber S, Selke B, Reilly MC, Sanborn W.  Moderate to severe Crohn's disease induces high productivity losses: Work Productivity and Activity Impairment (WPAI) baseline data from the PRECiSE program.  Digestive Disease Week.  May 20-25, 2006, Los Angeles, CA.

Fernandez HH, Jankovic J, Holds JB, Lin D, Burns J, Verma A, Sethi K, Pappert EJ. Observational Study of IncobotulinumtoxinA for Cervical Dystonia or Blepharospasm (XCiDaBLE): Interim Results for the First 170 Subjects with Blepharospasm. Tremor Other Hyperkinet Mov (N Y). 2014 Jul 16;4:238.

Fletcher MJ, Upton J, Taylor-Fishwick J, Buist SA, Jenkins C, Hutton J, Barnes N, Van Der Molen T, Walsh JW, Jones P, Walker S. COPD Uncovered: An International survey on the impact of chronic obstructive pulmonary disease (COPD) on a working age population. BMC Public Health. 2011 Aug 1;11(1):612. [Epub ahead of print]

Fourquet J, Báez L, Figueroa M, Iriarte RI, Flores I. Quantification of the impact of endometriosis symptoms on health-related quality of life and work productivity. Fertil Steril. 2011 May 28. [Epub ahead of print]

Fowler JF, Ghosh A, Sung J, Emani S, Chang J, Den E, Thorn D, Person J, Duh MS. Impact of chronic hand dermatitis on quality of life, work productivity, activity impairment, and medical costs. J Am Acad Dermatol. 2006;54(3):448-57.

Frederix GW, Quadri N, Hövels AM, van de Wetering FT, Tamminga H, Schellens JH, Lloyd AJ. Utility and Work Productivity Data for Economic Evaluation of Breast Cancer Therapies in the Netherlands and Sweden. Clin Ther. 2013 Mar 28.

Galaznik A, Chapnick J, Vietri J, Tripathi S, Zou KH, Makinson G. Burden of smoking on quality of life in patients with chronic obstructive pulmonary disease. Expert Rev Pharmacoecon Outcomes Res. 2013 Dec;13(6):853-60.

Garris C, Oglesby A, Sulcs E, Lee M. Impact of systemic lupus erythematosus on burden of illness and work productivity in the United States. Lupus. 2013;22(10):1077-86. 

Gawlicki MC, Reilly MC, Popielnicki A, Reilly K.  Linguistic validation of the US Spanish Work Productivity and Activity Impairment questionnaire, general health version (WPAI:GH). Presented ISPOR Tenth Annual International Meeting, May 17, 2005, Washington, DC.

Gawlicki MC, Reilly MC, Popielnicki A, Reilly K.  Linguistic validation of the US Spanish Work Productivity and Activity Impairment questionnaire, general health version (WPAI:GH). Value in Health. 2006; 9(3);199-204.

Genovese S, Tedeschi D. Effects of Vildagliptin/Metformin Therapy on Patient-Reported Outcomes: Work Productivity, Patient Satisfaction, and Resource Utilization. Adv Ther. 2013 Feb 20. [Epub ahead of print]

Gibson PR, Vaizey C, Black CM, Nicholls R, Weston AR, Bampton P, Sparrow M, Lawrance IC, Selby WS, Andrews JM, Walsh AJ, Hetzel DJ, Macrae FA, Moore GT, Weltman MD, Leong RW, Fan T. Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: A cross-sectional, observational study. J Crohns Colitis. 2013 Dec 14. 

Giovannetti ER, Wolff JL, Frick KD, Boult C. Construct Validity of the Work
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Gisbert JP, Cooper A, Karagiannis D, Hatlebakk J, Agréus L, Jablonowski H, Nuevo J. Impact of gastroesophageal reflux disease on work absenteeism, presenteeism and productivity in daily life: a European observational study. Health Qual Life Outcomes. 2009;7:90.

Glanz BI, Dégano IR, Rintell DJ, Chitnis T, Weiner HL, Healy BC. Work productivity in relapsing multiple sclerosis: associations with disability, depression, fatigue, anxiety, cognition, and health-related quality of life. Value Health. 2012 Dec;15(8):1029-35.

Gordon C, Isenberg D, Lerstrøm K, Norton Y, Nikaï E, Pushparajah DS, Schneider
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Goren A, Mould-Quevedo J, daCosta DiBonaventura M. Prevalence of Pain Reporting and Associated Health Outcomes Across Emerging Markets and Developed Countries. Pain Med. 2014 Sep 12.

Goren A, Zou KH, Gupta S, Chen C. Direct and indirect cost of urge urinary incontinence with and without pharmacotherapy. Int J Clin Pract. 2013 Dec 22. 

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Holloway L, Humphrey L, Heron L, Pilling C, Kitchen H, Højbjerre L, Strandberg-Larsen M, Hansen B. Patient-reported outcome measures for systemic lupus erythematosus clinical trials: a review of content validity, face validity and psychometric performance. Health Qual Life Outcomes. 2014 Jul 22;12(1):116. 

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Jain G, Roy A, Harikrishnan V, Yu S, Dabbous O, Lawrence C. Patient-reported Depression Severity Measured by the PHQ-9 and Impact on Work Productivity: Results From a Survey of Full-time Employees in the United States. J Occup Environ Med. 2013 Feb 22. [Epub ahead of print] 

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Jayathunge MP, Bowanwatanuwong C, Maek-A-nantawat W, Pitisuttithum BP.
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Johnson DA, Orr WC, Crawley JA, Traxler B, McCullough J, Brown KA, Roth T.
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Kahrilas PJ, Howden CW, Wernersson B, Denison H, Nuevo J, Gisbert JP. Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study. Aliment Pharmacol Ther. 2013 Apr 5. [Epub ahead of print]

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Kim LS, Riedlinger JE, Baldwin CM, Hilli L, Khalsa SV, Messer SA, Waters RF.
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Kimball AB, Bensimon AG, Guerin A, Yu AP, Wu EQ, Okun MM, Bao Y, Gupta SR,
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Kimball AB, Yu AP, Signorovitch J, Xie J, Tsaneva M, Gupta SR, Bao Y, Mulani
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Kimball AB, Jemec GB, Yang M, Kageleiry A, Signorovitch JE, Okun MM, Gu Y, Wang K, Mulani P, Sundaram M. Assessing the Validity, Responsiveness, and Meaningfulness of the Hidradenitis Suppurativa Clinical Response (HiSCR) as the Clinical Endpoint for Hidradenitis Suppurativa Treatment. Br J Dermatol. 2014 Jul 17. 

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Krishnarajah G, DiBonaventura M, Wagner S, Gupta S.  The effect of weight changes on health-related quality of life and work impairment in patients with type 2 diabetes. Poster presentation, ISPOR 14th Annual International Meeting, Orlando, FL, May 16, 2009.

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Lamori JC, Mody SH, Gross HJ, Dibonaventura MD, Patel A, Schein J, Nelson WW. 
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Leong RW, Huang T, Ko Y, Jeon A, Chang J, Kohler F, Kariyawasam V. Prospective validation study of the International Classification of Functioning, Disability and Health score in Crohn's disease and ulcerative colitis. J Crohns Colitis. 2014 Mar 21. 

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Liu GG, Dibonaventura MD, Yuan Y, Wagner JS, L'italien GJ, Langley P, Kamae I. The burden of illness for patients with viral hepatitis C: evidence from a national survey in Japan. Value Health. 2012 Jan;15(1 Suppl):S65-71. 

Loeppke R, Hymel PA, Lofland JH, Pizzi LT, Konicki DL, Anstadt GW, Baase C, Fortuna J, Scharf T; American College of Occupational and Environmental Medicine.Health-related workplace productivity measurement: general and migraine-specific recommendations from the ACOEM Expert Panel.J Occup Environ Med. 2003;45(4):349-59.

Louis E, Löfberg R, Reinisch W, Camez A, Yang M, Pollack PF, Chen N, Chao J, Mulani PM. Adalimumab improves patient-reported outcomes and reduces indirect costs in patients with moderate to severe Crohn's disease: Results from the CARE trial. J Crohns Colitis. 2012 Apr 3. [Epub ahead of print]

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Lynch W, Reidel JE, editors  Measuring employee productivity: a guide to self-assessment tools.  Institute for Health and Productivity Management amd William M. Mercer, Inc., Virginia, 2001.

Machado DA, Guzman RM, Xavier RM, Simon JA, Mele L, Pedersen R, Ferdousi T, Koenig AS, Kotak S, Vlahos B. Open-label observation of addition of etanercept versus a conventional disease-modifying antirheumatic drug in subjects with active rheumatoid arthritis despite methotrexate therapy in the latin american region. J Clin Rheumatol. 2014 Jan;20(1):25-33.

Malaguarnera G, Pennisi M, Gagliano C, Vacante M, Malaguarnera M, Salomone S, Drago F, Bertino G, Caraci F, Nunnari G, Malaguarnera M. Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α 2b Plus Ribavirin: Effect on Work Performance; A Randomized Clinical Trial. Hepat Mon. 2014 May 5;14(5):e11608. 

Malmberg I, Reimer C, Bytzer.  Population-based survey to assess impact of troublesome symptoms in gastroesophageal reflux disease on work productivity.  Poster presentation, ISPOR 11th Annual European Congress, Athens, Greece, November 09, 2008.

Maksymowych WP, Gooch KL, Wong RL, Kupper H, van der Heijde D. Impact of Age, Sex, Physical Function, Health-related Quality of Life, and Treatment with Adalimumab on Work Status and Work Productivity of Patients with Ankylosing Spondylitis. J Rheumatol. 2009 Dec 1. [Epub ahead of print]

Mansfield LE, Hampel F, Haeusler JM, Georges G. Study of levocetirizine in seasonal allergic rhinitis. Curr Med Res Opin. 2010 Jun;26(6):1269-75. 

Marrett E, Dibonaventura MD, Zhang Q. Burden of peripheral arterial disease in Europe and the United States: a patient survey. Health Qual Life Outcomes. 2013 Oct 22;11(1):175.

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McLeod LD, Fehnel SE, Zografos LJ et al.  The impact of restless Legs syndrome on various dimensions of life: results of a web-based patient survey.  International Society of Pharmacoeconomics and Outcomes Research, 12th Annual International Meeting, May 21-23, 2007.  Arlington, VA.

Meijs S, Gardenbroek TJ, Sprangers MA, Bemelman WA, Buskens CJ, D'Haens GR, Löwenberg M. Health-related quality of life and disability in patients with ulcerative colitis and proctocolectomy with ileoanal pouch versus treatment with anti-TNF agents. J Crohns Colitis. 2014 Jan 10. 

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Meltzer EO, Munafo DA, Chung W, Gopalan G, Varghese ST. Intranasal mometasone 
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Meyer TK, Hu A, Hillel AD. Voice disorders in the workplace: Productivity in spasmodic dysphonia and the impact of botulinum toxin. Laryngoscope. 2013 Nov; 123 Suppl6:S1-14.

Michael MD, Bálint A, Lovász BD, Gulácsi L, Strbák B, Golovics PA, Farkas K, Kürti Z, Szilágyi BK, Mohás A, Molnár T, Lakatos PL. Work disability and productivity loss in patients with inflammatory bowel diseases in Hungary in the era of biologics. Eur J Health Econ. 2014 May 16.

Mitcheson HD, Roy JB, Gilmet G, Marshall TS, Shannon JB.  Impact of solifenacin on symptom bother, health-related quality of life, work productivity, treatment satisfaction, and symptoms in patients with overactive bladder: results from VIBRANT. Poster presentation, ISPOR 14th Annual International Meeting, Orlando, FL, May 16, 2009.

Miller DP, Tom G, Rasouliyan L, Chipps B.  Patient-reported outcomes among omalizumab and salmeterol/fluticasone combination therapy patients. J Asthma. 2009 Mar;46(2):179-85.

Mitchell BD, Vietri J, Zagar A, Curtis B, Reaney M. Hypoglycaemic events in patients with type 2 diabetes in the United Kingdom: associations with patient-reported outcomes and self-reported HbA1c. BMC Endocr Disord. 2013 Dec 19;13(1):59.

Mody R, Bolge SC, Kannan H, Fass R. Effects of gastro-esophageal reflux disease on sleep and outcomes. Clin Gastroenterol Hepatol. 2009 Apr 15. [Epub ahead of print] 

Moline M, DiBonaventura Md, Shah D, Ben-Joseph R. Impact of middle-of-the-night awakenings on health status, activity impairment, and costs. Nat Sci Sleep. 2014 Jul 23;6:101-11.

Mukhekat V, Ahmad I, Merali Y, Aldulaimi D. PTU-078 The Application Of A Markov Model For Evauating Asa Therapy For Ulcerative Colitis. Gut. 2014 Jun;63 Suppl 1:A73.

Murota H, Kitaba S, Tani M, Wataya-Kaneda M, Azukizawa H, Tanemura A, Umegaki 
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Murray J, Nathan R, Bronsky E, Olufade AO, Chapman D, Kramer B.  Cetirizine in the management of seasonal allergic rhinitis: impact on patient health-related quality of life (HRQL), work productivity and activity impairment (WPAI).  Presented 1999 Annual Meeting of the American College of Allergy Asthma and Immunology (ACAAI), November 12-17, 1999.

Murray JJ, Nathan RA, Bronsky EA, Olufade AO, Chapman D, Kramer B.  Comprehensive evaluation of cetirizine in the management of seasonal allergic rhinitis: impact on symptoms, quality of life, productivity, and activity impairment.  Allergy Asthma Proc 2002,23 (6):391-8.

Meyer N, Paul C, Feneron D, Bardoulat I, Thiriet C, Camara C, Sid-Mohand D, Le Pen C, Ortonne JP. Psoriasis: an epidemiological evaluation of disease burden in 590 patients. J Eur Acad Dermatol Venereol. 2010 Mar 4. [Epub ahead of print]

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Nuevo Rivero J, Tafalla García M, Zapardiel Ferrero J, Pérez Gisbert J. [Use of health resources and loss of productivity in gastroesophageal reflux disease: results of a cross-sectional study in a Primary Care setting in Spain.]. Aten Primaria. 2011 Mar 5. [Epub ahead of print] Spanish.

Nordyke RJ, Aguilar D, Lee A, Singh A, Tedeschi MR, Dubois RW.  Linking symptoms diurnality to productivity loss- a new conceptual approach.Value in Health 2005 (8):372-3.

Nordyke RJ, Aguilar D, Lee A, Singh A, Tedeschi MR, Dubois RW.  Linking symptoms diurnality to productivity loss- a new conceptual approach. Presented ISPOR Tenth Annual International Meeting, May 17, 2005, Washington, DC.

Okuda M, Crawford B, Juniper E, Leahy MJ. [Preparation of Japanese versions of rinoconjunctivitis quality of life questionnaire (RQLQ) and work productivity and activity impairment questionnaire (WPAI-AS)] Arerugi. 2003 Jul;52 Suppl 1:70-86. Japanese. 

Okubo K, Gotoh M, Shimada K, Ritsu M, Okuda M, Crawford B. Fexofenadine improves the quality of life and work productivity in Japanese patients with seasonal allergic rhinitis during the peak cedar pollinosis season.  Int Arch Allergy Immunol. 2005;136(2):148-154.

Papp KA, Signorovitch J, Ramakrishnan K, Yu AP, Gupta SR, Bao Y, Mulani PM.
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Papp KA, Sundaram M, Bao Y, Williams DA, Gu Y, Signorovitch JE, Wang Y, Valdes JM, Mulani PM. Effects of briakinumab treatment for moderate to severe psoriasis on health-related quality of life and work productivity and activity impairment: results from a randomized phase III study. J Eur Acad Dermatol Venereol. 2013 May 17.doi: 10.1111/jdv.12177. [Epub ahead of print]

Pare P, Lam S, Balshaw R, Keown P, Khorasheh S, Barbeau M, McBurney.  Patient characteristics (irritable bowel syndrome with constipation [IBS-C]): baseline results from LOGIC (Longitudinal Outcomes study of GI symptoms in Canada).  Presented American College of Gastroenterology October 30, 2005, Honolulu, Hawaii.

Paré P, Gray J, Lam S,Balshaw R, Khorasheh S, Barbeau M, Kelly S, McBurney CR. Health-Related Quality of Life, Work Productivity, and Health Care Resource Utilization of Subjects with Irritable Bowel Syndrome: Baseline Results from LOGIC (Longitudinal Outcomes study of GastroIntestinal symptoms in Canada), a Naturalistic Study. Clin Ther. 2006:28(10):1726-35.

Patel VD, Watanabe JH, Strauss JA, Dubey AT. Work productivity loss in
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Pavelka K, Szekanecz Z, Damjanov N, Majdan M, Nasonov E, Mazurov V, Fabo T,
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Pearce DJ, Singh S, Balkrishnan R, Kulkarni A, Fleischer AB, Feldman SR. The negative impact of psoriasis on the workplace. J Dermatolog Treat. 2006;17(1):24-8. 

Péntek M, Gulácsi L, Majoros A, Piróth C, Rubliczky L, Böszörményi Nagy G, Törzsök F, Timár P, Baji P, Brodszky V. [Health related quality of life and productivity of women with overactive bladder]. Orv Hetil. 2012 Jul 8;153(27):1068-76. Hungarian.

Perrillo R, Rothstein KD, Rubin R, Alam I, Imperial J, Harb G, Hu S, Klaskala W. Comparison of quality of life, work productivity and medical resource utilization of peginterferon alpha 2a vs the combination of interferon alpha 2b plus ribavirin as initial treatment in patients with chronic hepatitis C. J Viral Hepat. 2004 Mar;11(2):157-65. 

Phonrat B, Ruengkris T, Naksrisook S, Intalapaporn K, Jirakorbchaipong P, Pitisuttithum P. Psychosocial burden of women with abnormal Pap smears.  Southeast Asian J Trop Med Public Health. 2009;40(3):593-601.

Pollack, M, Bolge SC, Williams S, Waterman F. The association between patient-reported diabetes symptoms and tolerability issues of oral antidiabetic agents on work and life productivity.  Poster presentation, ISPOR 14th Annual International Meeting, Orlando, FL, May 16, 2009.

Prasad M, Shih YCT, Wahlqvist P, Shikiar R. A critical review of health-related productivity measures. Value in Health 2002;5(6):A535-6.

Prasad M, Shih YCT, Wahlqvist P, Shikiar R. A review of self-report instruments measuring health-related work productivity. Pharmacoeconomics 2004:22(4); 225-244.

Radner H, Smolen JS, Aletaha D. Remission in rheumatoid arthritis: benefit over low disease activity in patient reported outcomes and costs. Arthritis Res Ther. 2014 Feb 21;16(1):R56.

Reilly MC, Barghout V, McBurney CR.  Effect of tegaserod on work and daily activity: results from ZENSAA..  Presented 13th World Congress of Gastroenterology, Montreal, Canada September 10-14, 2005.

Reilly MC, Barghout V, McBurney CR, Niecko TE.  Effect of tegaserod on work and daily activity in IBS with constipation.  Aliment Pharmacol & Ther 2005; 22:373-380. 

Reilly MC, Barghout V, Ruegg P, Pecher E, Ricci J-F.  Tegaserod significantly reduces work productivity loss and daily activity impairment in patients with IBS with constipation.  Am J Gastroenterol 2004;99(10):S241.

Reilly MC, Bracco A, Geissler K, Johanson J, Kahler KH.  Impact of irritable bowel syndrome (IBS) on work productivity and daily activities.  Presented 69th Annual Meeting American College of Gastroenterology,: Orlando FL, 3 Nov 2004.

Reilly MC, Bracco A, Ricci J-F, Santoro J, Stevens T.  The validity and accuracy of the Work Productivity and Activity Impairment questionnaire - irritable bowel syndrome version (WPAI:IBS).   Aliment  Pharmacol Ther 2004; 20:459-467.

Reilly MC, Brown MCJ, Brabant Y, et al. Minimally important difference for WPAI:CD scores: Defining relevant impact on work productivity in active Crohn’s disease (Abst 962). Presented at the American College of Gastroenterology Annual Scientific Meeting; Philadelphia. October 12 to 17, 2007.

Reilly MC, Gerlier L, Brabant Y, Brown, M. Validity, reliability and responsiveness of the Work Productivity and Activity Impairment questionnaire in Crohn’s disease. Clin Ther. 2008; 30(2):393-404.

Reilly MC, Gerlier L, Brown, M. Discriminant validity of the Work Productivity and Activity Impairment questionnaire in patient’s with Crohn’s disease. Value in Health. 2006; 9(6):A246. (Abstract.)

Reilly MC, Gerlier L, Brown, M. Discriminant validity of the Work Productivity and Activity Impairment questionnaire in patient’s with Crohn’s disease. Presented ISPOR 9th Annual European Congress, Copenhagen, Denmark, October 28-30, 2006.

Reilly MC, Gooch KL, Wong RL, Kupper H, van der Heijde D,  Validity, reliability and responsiveness of the Work Productivity and Activity Impairment Questionnaire in ankylosing spondylitis . Rhuematology 2010; Jan 25. [Epub ahead of print].

Reilly M, Lavin P, Kahler K. Quality of life and work productivity analysis of patients with mild to moderate chronic hand dermatitis.  Presented American Academy of Dermatology, 60th Annual Meeting, Feb. 22-27, 2002.

Reilly M, Lavin P, Kahler K.  Effect of pimecrolimus cream 1% on quality of life and work productivity outcomes of patients with mild to moderate chronic hand dermatitis.  Presented American Academy of Dermatology, 60th Annual Meeting, Feb. 22-27, 2002.

Reilly M, Lavin P, Kahler K.  Validation of quality of life and work productivity instruments in patients with chronic hand dermatitis.  Presented American Academy of Dermatology, 60th Annual Meeting, Feb. 22-27, 2002.

Reilly MC, Lavin PT, Kahler KH, Pariser DM.  Validation of the Dermatology Life Quality Index (DLQI) and the Work Productivity and Activity Impairment: Chronic Hand Dermatitis Questionnaire (WPAI-ChHD) in Chronic Hand Dermatitis (ChHD).  J Am Academy Dermatol.2003;48:128-30.

Reilly MC, McBurney CR.  Responsiveness of the Work Productivity and Activity Impairment Questionnaire for Irritable Bowel Syndrome with Constipation (WPAI:IBS-C) to clinically meaningful change.  Presented American College of Gastroenterology October 30, 2005, Honolulu, Hawaii.

Reilly MC, McBurney CR, Bracco A. Responsiveness of the Work Productivity and Activity Impairment questionnaire for irritable bowel syndrome with constipation (WPAI:IBS-C) to clinically meaningful change. Am J Gastroenterol 2005; 100(9): S762. (Abstract)

Reilly MC, McBurney CR, Bracco A. Work absenteeism in irritable bowel syndrome (IBS): measuring days versus hours missed.  Presented ISPOR 8th Annual European Congress, Nov 6-8, 2005, Florence, Italy.

Reilly M, Mitchell I, Gooch K, Vo P, Virabhak S, Lorimer M, Ruff M,Seidenberg J,Khong H Preliminary Validation of the Work Productivity Activity Impairment (WPAI) in Caregivers of Children Hospitalized for Respiratory Illness (WPAI:CHRI) in Germany and Canada. Poster presentation at ISPOR Asia, Taipei, Taiwan, Sept 4 2012. 

Reilly MC, Relkin N, Zbrozek A. Development and testing of a new outcome measure of relationship between patients with Alheimer's disease and their partners.  Am J Alzheimer's Dis and Other Dementias. 2006; 21(4):249-257.

Reilly MC, Tanner A, Meltzer EO.  Allergy impairment questionnaires: validation studies.  J Allergy Clin Immunology 1996;97:1:3:430.

Reilly MC, Tanner A, Meltzer EO. Work, classroom and activity impairment instruments: validation studies in allergic rhinitis.  Clinical Drug Investigations 1996; 11(5):278-288.  Please note there is an error in the sample size calculations. We state (page 287) that 201 patients per treatment group would be required to detect a 5% difference in overall work impairment and 1,256 patients would be required to detect a 2% difference.  The numbers should be 190 patients and 1,180 patients, respectively.  For overall classroom impairment, the sample size per treatment group should be 290 patients, not 192 patients.

Reilly MC, Zbrozek AS, Dukes EM.  The validity and reproducibility of a work productivity and activity impairment instrument.  PharmacoEconomics 1993; 4(5):353-65.

Revicki DA, Willian MK, Menter A, Gordon KB, Kimball AB, Leonardi CL, Langley 
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Tillett W, Shaddick G, Askari A, Cooper A, Creamer P, Clunie G, Helliwell PS, Kay L, Korendowych E, Lane S, Packham J, Shaban R, Williamson L, McHugh N. Factors influencing work disability in psoriatic arthritis: first results from a large UK multicentre study. Rheumatology (Oxford). 2014 Aug 13. 

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Trivedi MH, Morris DW, Wisniewski SR, Lesser I, Nierenberg AA, Daly E, Kurian BT, Gaynes BN, Balasubramani GK, Rush AJ. Increase in Work Productivity of Depressed Individuals With Improvement in Depressive Symptom Severity. Am J Psychiatry. 2013 Apr 5. [Epub ahead of print]

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Wahlqvist P, Bergenheim K, Långström G, Næsdal J. Impact on work productivity of upper gastrointestinal symptoms associated with chronic NSAID therapy in a Swedish study population. Value in Health 2003;6(6):A688.

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Wahlqvist P, Carlsson J, Stalhammar NO, Wiklund I.  Validity of a Work Productivity and Activity Impairment questionnaire for patients with symptoms of gastro-esophageal reflux disease (WPAI-GERD)- results from a cross-sectional study.  Value in Health 2002; 5:106-113.

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Updated August 24, 2015

All References
Validation
Reviews

By use:



Anemia
Angioedema
Ankylosing Spondylitis
Arthritis
Asthma /Allergies
Cancer
Caregivers
Crohn's Disease
COPD
Dermatology
Diabetes
Dyspepsia
Erectile Dysfunction
Eye Disease
GERD
General Health
Gout
Headache



Hepatitis
HIV/AIDS
Hypertension
Inflammatory Bowel Disease
IBS/Chronic Constipation
Lupus
Mental Health
Multiple Sclerosis
Neurology
Nocturia
Obesity/ Nutrition
Overactive Bladder
Pain
PAD



Respiratory
Restless Legs Syndrome
Rhinosinusitis
Sleep
Spondyloarthritis 
Substance Abuse
Ulcerative Colitis
Urinary Incontinence
Voice Disorders
Women's Health