REILLY ASSOCIATES
 WPAI References

Bixquert M, Calleja J, Maldonado J, Ballesteros E, Vara S, Rico-Villademoros F.  Impact of nocturnal heartburn on quality of life, sleep and productivity: the Sinerge Study.  Presented 12th United European Gastroenterology Week UEGW , 25-29 Sept. 2004, Prague, Czech Republic.

Bixquert M, Calleja J, Maldonado J, Ballesteros E, Vara S, Rico-Villademoros F.  Impact of nocturnal heartburn on quality of life, sleep and productivity: the Sinerge Study.  Gut 2004; 53(Suppl V1)A99.

Brozek JL, Guyatt GH, Heels-Ansdell D, Degl'Innocenti A, Armstrong D, Fallone 
CA, Wiklund I, van Zanten SV, Chiba N, Barkun AN, Akl EA, Schünemann HJ. Specific HRQL instruments and symptom scores were more responsive than preference-based generic instruments in patients with GERD. J Clin Epidemiol. 2009;62(1):102-10. Epub 2008 Jul 10.

Bruley des Varannes S, Ducrotté P, Vallot T, Garofano A, Bardoulat I, Carrois F, Ricci L. Gastroesophageal reflux disease: Impact on work productivity and daily-life activities of daytime workers. A French cross-sectional study. Dig Liver Dis. 2012 Dec 10.

Calleja JL, Bixquert M, Maldonado J; for the SINERGE Study Group. Impact of Nocturnal Heartburn on Quality of Life, Sleep, and Productivity: The SINERGE Study. Dig Dis Sci. 2006 Jul 29; [Epub ahead of print] 

Dean BB, Crawley JA, Reeves JD, Aguilar D, Sullivan S.  The cost of gastroesophageal reflux disease: it's what you don't see that counts.  JMCM 2003; 7(2): 6-13.

Dean BB, Crawley JA, Schmitt CM, Wong J, Ofman JJ.  The burden of illness of gastro-oesophageal reflux disease: impact on work productivity.  Alimentary Pharmacology  & Therapeutics 2003:17 (10): 1309-1317.

Dean BB, Crawley JA, Schmitt CM., Ofman JJ.  The Impact of GERD Symptoms on Worker Productivity and Absenteeism.  Presented ACG Meeting 2001.

Dean BB, Crawley JA, Schmitt CM., Ofman JJ. The Association Between Worker Productivity and Quality of Life in GERD.  Presented ACG Meeting 2001.

Gisbert JP, Cooper A, Karagiannis D, Hatlebakk J, Agréus L, Jablonowski H, Nuevo J. Impact of gastroesophageal reflux disease on work absenteeism, presenteeism and productivity in daily life: a European observational study. Health Qual Life Outcomes. 2009;7:90.

Ekesbo R, Sjöstedt S, Sörngård H. Effects of Structured Follow-Up and of More 
Effective Acid Inhibitory Treatment in the Management of GORD Patients in a
Swedish Primary-Care Setting: A Randomized, Open-Label Study. Clin Drug Investig.
2011;31(3):181-9.

El-Dika S, Guyatt GH, Armstrong D, Degl'innocenti A, Wiklund I et al.  The impact of illness in patients with moderate to severe gastro-esophageal reflux disease.  BMC Gastroenterol. 2005; 5: 23. Published online 2005 July 10.

Gross M, Beckenbauer U, Burkowitz J, Walther H, Brueggenjuergen B. Impact of gastro-oesophageal reflux disease on work productivity despite therapy with proton pump inhibitors in Germany. Eur J Med Res. 2010;15(3):124-30.

Johnson D, Crawley JA, Hwang C, Brown K. Clinical trial: esomeprazole for moderate-to-severe nighttime heartburn and gastro-oesophageal reflux disease-related sleep disturbances. Aliment Pharmacol Ther. 2010.;32(2):182-90. Epub 2010 Apr 29.

Johnson DA, Orr WC, Crawley JA, Traxler B, McCullough J, Brown KA, Roth T. Effect of Esomeprazole on Nighttime Heartburn and Sleep Quality in Patients with GERD: A Randomized, Placebo-Controlled Trial.Am J Gastroenterol. 2005;100(9):1914-22.

Johnson D, Orr W, Crawley J, Cuccia A, Truxler B, Brown K, Roth T.  Espomeprazole reduces the costs of reduced work productivity due to GERD-related sleep disturbances.  Am J Gatroenterology, October, 2004; 99(Suppl 10, abstract): S233.

Kahrilas PJ, Howden CW, Wernersson B, Denison H, Nuevo J, Gisbert JP. Impact of persistent, frequent regurgitation on quality of life in heartburn responders treated with acid suppression: a multinational primary care study. Aliment Pharmacol Ther. 2013 Apr 5. [Epub ahead of print]

Malmberg I, Reimer C, Bytzer.  Population-based survey to assess impact of troublesome symptoms in gastroesophageal reflux disease on work productivity.  Poster presentation, ISPOR 11th Annual European Congress, Athens, Greece, November 09, 2008.

Mody R, Bolge SC, Kannan H, Fass R. Effects of gastro-esophageal reflux disease on sleep and outcomes. Clin Gastroenterol Hepatol. 2009 Apr 15. [Epub ahead of print] 

Nuevo Rivero J, Tafalla García M, Zapardiel Ferrero J, Pérez Gisbert J. [Use of health resources and loss of productivity in gastroesophageal reflux disease: results of a cross-sectional study in a Primary Care setting in Spain.]. Aten Primaria. 2011 Mar 5. [Epub ahead of print] Spanish.

Nordyke RJ, Aguilar D, Lee A, Singh A, Tedeschi MR, Dubois RW.  Linking symptoms diurnality to productivity loss- a new conceptual approach. Value in Health 2005 (8):372-3.

Nordyke RJ, Aguilar D, Lee A, Singh A, Tedeschi MR, Dubois RW.  Linking symptoms diurnality to productivity loss- a new conceptual approach. Presented ISPOR Tenth Annual International Meeting, May 17, 2005, Washington, DC.

Shin WG, Kim HU, Kim SG, Kim GH, Shim KN, Kim JW, Kim JI, Kim JG, Kim JJ, Yim 
DH, Park SK, Park SH; The Korean College of Helicobacter and Upper Gastrointestinal Research. Work productivity and activity impairment in gastroesophageal reflux disease in Korean full-time employees: A multicentre study. Dig Liver Dis. 2012 Apr;44(4):286-291. Epub 2012 Feb 9.

Suzuki H, Matsuzaki J, Masaoka T, Inadomi JM. Greater loss of productivity among Japanese workers with gastro-esophageal reflux disease (GERD) symptoms that persist vs resolve on medical therapy. Neurogastroenterol Motil. 2014 Feb 25.

Toghanian S, Johnson DA, Stålhammar NO, Zerbib F. Burden of Gastro-Oesophageal
Reflux Disease in Patients with Persistent and Intense Symptoms Despite Proton Pump Inhibitor Therapy: A Post Hoc Analysis of the 2007 National Health and Wellness Survey. Clin Drug Investig. 2011 Jul 14. doi:10.2165/11595480-000000000-00000. [Epub ahead of print]

Wagner JS, Dibonaventura MD, Balu S, Buchner D. The burden of diurnal and
nocturnal gastroesophageal reflux disease symptoms. Expert Rev Pharmacoecon
Outcomes Res. 2011 Dec;11(6):739-49.

Wahlqvist P, Symptoms of gastroesophageal reflux disease, perceived productivity, and health-realted quality of life.  Amer J Gastroenter 2001; 96(suppl.): S57-S61.

Wahlqvist P, Bergenheim K, Långström G, Næsdal J. Resolution of upper gastrointestinal symptoms associated with chronic non-steroidal anti-inflammatory drug therapy has a positive impact on patient-reported productivity. Gut 2003;52(Suppl VI):A226.

Wahlqvist P, Bergenheim K, Långström G, Næsdal J. Resolution of upper gastrointestinal symptoms associated with chronic non-steroidal anti-inflammatory drug therapy has a positive impact on patient-reported productivity.  Presented 11th United European Gastroenterology Week, November 1-5, 2003, Madrid Spain.

Wahlqvist P, Bergenheim K, Långström G, Næsdal J. Impact on work productivity of upper gastrointestinal symptoms associated with chronic NSAID therapy in a Swedish study population. Value in Health 2003;6(6):A688.

Wahlqvist P, Bergenheim K, Långström G, Næsdal J. Impact on work productivity of upper gastrointestinal symptoms associated with chronic NSAID therapy in a Swedish study population. Presented ISPOR 6th Annual European Congress, 9-11 November 2003, Barcelona, Spain.

Wahlqvist P, Carlsson J, Stalhammar NO, Wiklund I.  Validity of a Work Productivity and Activity Impairment questionnaire for patients with symptoms of gastro-esophageal reflux disease (WPAI-GERD)- results from a cross-sectional study.  Value in Health 2002; 5:106-113.

Wahlqvist P, Carlsson J. Correlation between different productivity variables obtained from the WPAI-GERD questionnaire. Value in Health 2002;5(6):A505-6.

Wahlqvist P, Guyatt GH, Armstrong D, Degl'innocenti A, Heels-Ansdell D, El-Dika
S, Wiklund I, Fallone CA, Tanser L, Veldhuyzen van Zanten S, Austin P, Barkun AN, Chiba N, Schünemann HJ.The Work Productivity and Activity Impairment Questionnaire for Patients with Gastroesophageal Reflux Disease (WPAI-GERD): Responsiveness to Change and English Language Validation. Pharmacoeconomics. 2007;25(5):385-96.

Wahlqvist P, Guyatt G, Armstrong D, Austin P, Barkun A, Chiba N, degl'Innocenti A, El-Dika S, Fallone C, Heels-Ansdell D, Tanser L, Veldhuyzen van Zanten S, Wiklund I, Schünemann H. Responsiveness to change and English language validation of the WPAI-GERD questionnaire - results from a Canadian study. Value in Health 2004;7(3):A349.

Wahlqvist P, Guyatt G, Armstrong D, Austin P, Barkun A, Chiba N, degl'Innocenti A, El-Dika S, Fallone C, Heels-Ansdell D, Tanser L, Veldhuyzen van Zanten S, Wiklund I, Schünemann H. Responsiveness to change and English language validation of the WPAI-GERD questionnaire - results from a Canadian study. Presented ISPOR Congress, May 2004.

Wahlqvist P, Karlsson M, Johnson D, Carlsson J, Bolge SC, Wallander MA.  Relationship between symptom load of gastroesophageal reflux disease and health-related quality of life, work productivity, resource utilization and concomitant diseases: survey of a US cohort. Aliment Pharmacol Ther. 2008 Feb 29; [Epub ahead of print]

Wahlqvist P, Karlsson M, Johnson D, Carlsson J, Bolge SC, Wallander MA.  Relationship between gastroesophageal reflux disease and costs: a database study in a US cohort.  Value in Health 2007;10(3):A149.

Wahlqvist P, Karlsson M, Johnson D, Carlsson J, Bolge SC, Wallander MA.  Symptoms of gastroesophageal reflux disease, concomitant diseases, health-related quality of life and work productivity: a database study in a US cohort.  Value in Health 2007;10(3):A152.

Wahlqvist P, Medin J, Karlsson M, Reilly MC. Responsiveness to change and construct validity of the Work Productivity and Activity Impairment questionnaire for gastroesophageal reflux disease (WPAI:GERD) in Swedish patients.  Poster presentation, ISPOR 14th Annual International Meeting, Orlando, FL, May 16, 2009.

Wahlqvist P, Reilly M, Barkun A. The impact of gastroesophageal reflux disease on work productivity: a systematic review. Value in Health 2005;8(6):A122.

Wahlqvist P, Reilly M, Barkun A. The impact of gastroesophageal reflux disease on work productivity: a systematic review. Presented ISPOR 8th Annual European Conference, 6-8 November 2005, Florence Italy.

Wahlqvist P, Reilly M, Barkun A. Systematic review: the impact of gastro-oesophageal reflux disease on work productivity. Alimentary Pharmacology & Therapeutics 2006:24(2):259-272.
COPD

Allen-Ramey FC, Gupta S, Dibonaventura MD. Patient characteristics, treatment patterns, and health outcomes among COPD phenotypes. Int J Chron Obstruct Pulmon Dis. 2012;7:779-87.

Dacosta Dibonaventura M, Paulose-Ram R, Su J, McDonald M, Zou KH, Wagner JS, Shah H. The Impact of COPD on Quality of Life, Productivity Loss, and Resource Use among the Elderly United States Workforce. COPD. 2012 Feb;9(1):46-57.

Dibonaventura MD, Paulose-Ram R, Su J, McDonald M, Zou KH, Wagner JS, Shah H. 
The burden of chronic obstructive pulmonary disease among employed adults. Int J 
Chron Obstruct Pulmon Dis. 2012;7:211-9. 

Fletcher MJ, Upton J, Taylor-Fishwick J, Buist SA, Jenkins C, Hutton J, Barnes N, Van Der Molen T, Walsh JW, Jones P, Walker S. COPD Uncovered: An International survey on the impact of chronic obstructive pulmonary disease (COPD) on a working age population. BMC Public Health. 2011 Aug 1;11(1):612.

Galaznik A, Chapnick J, Vietri J, Tripathi S, Zou KH, Makinson G. Burden of smoking on quality of life in patients with chronic obstructive pulmonary disease. Expert Rev Pharmacoecon Outcomes Res. 2013 Dec;13(6):853-60.

Solem CT, Sun SX, Sudharshan L, Macahilig C, Katyal M, Gao X. Exacerbation-related impairment of quality of life and work productivity in severe and very severe chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2013;8:641-52. 

Stahl E, Jansson SA, Jonsson AC, Svensson K, Lundback B, Andersson F.  Health-related quality of life, utility, and productivity outcomes instruments: ease of completion by subjects with COPD.  Health Qual Life Outcomes 2003; 1(1):18.

Troosters T, Sciurba FC, Decramer M, Siafakas NM, Klioze SS, Sutradhar SC, Weisman IM, Yunis C. Tiotropium in patients with moderate COPD naive to maintenance therapy: a randomised placebo-controlled trial. NPJ Prim Care Respir Med. 2014 May 20;24:14003.


Dermatology
Chan B, Hales B, Shear N, Ho V, Lynde C, Poulin Y, Mittmann N. Work-related lost productivity and its economic impact on Canadian patients with moderate to severe psoriasis. J Cutan Med Surg. 2009;13(4):192-7. 

Fowler JF, Ghosh A, Sung J, Emani S, Chang J, Den E, Thorn D, Person J, Duh MS. Impact of chronic hand dermatitis on quality of life, work productivity, activity impairment, and medical costs. J Am Acad Dermatol. 2006;54(3):448-57.

Hayashi M, Saeki H, Ito T, Fukuchi O, Umezawa Y, Katayama H, Tanito K, Igarashi A, Etoh T, Hasegawa T, Nakagawa H. Impact of disease severity on work productivity and activity impairment in Japanese patients with psoriasis. J Dermatol Sci. 2013 Nov;72(2):188-91. 

Heelan K, Hitzig SL, Knowles S, Drucker AM, Mittmann N, Walsh S, Shear NH.
Loss of Work Productivity and Quality of Life in Patients With Autoimmune Bullous
Dermatoses. J Cutan Med Surg. 2015 Apr 17.

Kimball AB, Bensimon AG, Guerin A, Yu AP, Wu EQ, Okun MM, Bao Y, Gupta SR, Mulani PM. Efficacy and Safety of Adalimumab among Patients with Moderate to Severe Psoriasis with Co-Morbidities: Subanalysis of Results from a Randomized, Double-Blind, Placebo-Controlled, Phase III Trial. Am J Clin Dermatol. 2011 Feb  1;12(1):51-62. 

Kimball AB, Jemec GB, Yang M, Kageleiry A, Signorovitch JE, Okun MM, Gu Y, Wang K, Mulani P, Sundaram M. Assessing the Validity, Responsiveness, and Meaningfulness of the Hidradenitis Suppurativa Clinical Response (HiSCR) as the Clinical Endpoint for Hidradenitis Suppurativa Treatment. Br J Dermatol. 2014 Jul 17. 

Kimball AB, Yu AP, Signorovitch J, Xie J, Tsaneva M, Gupta SR, Bao Y, Mulani 
work productivity and activity impairment for patients with moderate to severe
psoriasis. J Am Acad Dermatol. 2011 May 24.

Lewis-Beck C, Abouzaid S, Xie L, Baser O, Kim E. Analysis of the relationship between psoriasis symptom severity and quality of life, work productivity, and activity impairment among patients with moderate-to-severe psoriasis using structural equation modeling. Patient Prefer Adherence. 2013;7:199-205.

Murota H, Kitaba S, Tani M, Wataya-Kaneda M, Katayama I.  Effects of nonsedative antihistamines on productivity of patients with pruritic skin diseases.  Allergy. 2009 Nov 4. [Epub ahead of print].

Murota H, Kitaba S, Tani M, Wataya-Kaneda M, Azukizawa H, Tanemura A, Umegaki N, Terao M, Kotobuki Y, Katayama I. Impact of Sedative and Non-Sedative Antihistamines on the Impaired Productivity and Quality of Life in Patients with Pruritic Skin Diseases. Allergol Int. 2010 Aug 25;59(4). 

Meyer N, Paul C, Feneron D, Bardoulat I, Thiriet C, Camara C, Sid-Mohand D, Le Pen C, Ortonne JP. Psoriasis: an epidemiological evaluation of disease burden in 590 patients. J Eur Acad Dermatol Venereol. 2010 Mar 4. 

Papp KA, Signorovitch J, Ramakrishnan K, Yu AP, Gupta SR, Bao Y, Mulani PM. Effects of Adalimumab versus Placebo on Risk of Symptom Worsening in Psoriasis and Subsequent Impacts on Health-Related Quality-of-Life: Analysis of Pooled Data from Two Randomized, Double-Blind, Placebo-Controlled, Multicentre Clinical Trials. Clin Drug Investig. 2010 Oct 8.

Papp KA, Sundaram M, Bao Y, Williams DA, Gu Y, Signorovitch JE, Wang Y, Valdes JM, Mulani PM. Effects of briakinumab treatment for moderate to severe psoriasis on health-related quality of life and work productivity and activity impairment: results from a randomized phase III study. J Eur Acad Dermatol Venereol. 2013 May 17.

Pearce DJ, Singh S, Balkrishnan R, Kulkarni A, Fleischer AB, Feldman SR. The negative impact of psoriasis on the workplace. J Dermatolog Treat. 2006;17(1):24-8.

Reilly M, Lavin P, Kahler K. Quality of life and work productivity analysis of patients with mild to moderate chronic hand dermatitis.  Presentated American Academy of Dermatology, 60th Annual Meeting, Feb. 22-27, 2002.

Reilly M, Lavin P, Kahler K.  Effect of pimecrolimus cream 1% on quality of life and work productivity outcomes of patients with mild to moderate chronic hand dermatitis.  Presented American Academy of Dermatology, 60th Annual Meeting, Feb. 22-27, 2002.

Reilly M, Lavin P, Kahler K.  Validation of quality of life and work productivity instruments in patients with chronic hand dermatitis.  Presented American Academy of Dermatology, 60th Annual Meeting, Feb. 22-27, 2002.

Reilly MC, Lavin PT, Kahler KH, Pariser DM.  Validation of the Dermatology Life Quality Index (DLQI) and the Work Productivity and Activity Impairment: Chronic Hand Dermatitis Questionnaire (WPAI-ChHD) in Chronic Hand Dermatitis (ChHD).  J Am Academy Dermatol.2003;48:128-30.

Revicki DA, Willian MK, Menter A, Gordon KB, Kimball AB, Leonardi CL, Langley 
RG, Kimel M, Okun M.  Impact of adalimumab treatment on patient-reported outcomes: Results from a Phase III clinical trial in patients with moderate to severe plaque psoriasis. J Dermatolog Treat. 2007;18(6):341-50.

Spector SL, Shikiar R, Harding G, Meeves S, Leahy MJ.  The effect of fexofenadine hydrochloride on productivity and quality of life in patients with chronic idiopathic urticaria. Cutis. 2007;79(2):157-62. 

Strober BE, Sobell JM, Duffin KC, Bao Y, Guérin A, Yang H, Goldblum O, Okun MM, Mulani PM. Sleep quality and other patient-reported outcomes improve after psoriasis patients with suboptimal response to other systemic therapies are switched to adalimumab: results from PROGRESS, an open-label Phase IIIB trial. Br J Dermatol. 2012 Aug 16. 

Vender R, Lynde C, Ho V, Chau D, Poulin-Costello M. Work Productivity and Healthcare Resource Utilization Outcomes for Patients on Etanercept for Moderate-to-Severe Plaque Psoriasis: Results from a 1-Year, Multicentre, Open-Label, Single-Arm Study in a Clinical Setting. Appl Health Econ Health Policy. 2012 Aug 9.

Wladysiuk M., Fedyna M., Bebrysz M., Rutkowski J., Haldas M. Impact of psoriasis on work status and work productivity. Results of Polish cross-sectional study. Presented 4th Congress of the Psoriasis International Network, Jul 4-6 2013, Paris, France.

Wladysiuk M., Bebrysz M., Fedyna M., Haldas M., Rutkowski J. What determines work productivity loss in rheumatoid arthritis (RA), Crohn’s disease (CD) and psoriasis (Ps) in Poland. Results of Move to Work (M2W) study. Presented ISPOR 19th Annual International Meeting, May 31-June 4 2014, Montreal, Canada.

Wladysiuk M., Fedyna M., Haldas M., Rutkowski J., Bebrysz M. Indirect costs of rheumatoid arthritis, Crohn’s disease and psoriasis in Poland. Presented HTAi 11th Annual Meeting, Jun 16-18, Washington DC, USA.

Wu Y, Mills D, Bala M. Impact of psoriasis on patients' work and productivity: a retrospective, matched case-control analysis. Am J Clin Dermatol. 2009;10(6):407-10.

Yano C, Saeki H, Ishiji T, Ishiuji Y, Sato J, Tofuku Y, Nakagawa H. Impact of disease severity on work productivity and activity impairment in Japanese patients with atopic dermatitis. J Dermatol. 2013 Jul 9.





GERD
Diabetes
Bolge SC, Samuel W.  Burden of illness of depression symptoms among patients with type 2 diabetes mellitus.  Poster presentation, ISPOR 14th Annual International Meeting, Orlando, FL, May 16, 2009.

Dacosta Dibonaventura M, Cappelleri JC, Joshi AV. A Longitudinal Assessment of Painful Diabetic Peripheral Neuropathy on Health Status, Productivity, and Health Care Utilization and Cost. Pain Med. 2010 Nov 18.

Dibonaventura MD, Cappelleri JC, Joshi AV. Association between Pain Severity and 
Painful Diabetic Peripheral Neuropathy Patients. Pain Med. 2011 Apr 11.

Dibonaventura M, Link C, Pollack MF, Wagner JS, Williams SA. The Relationship 
Between Patient-Reported Tolerability Issues With Oral Antidiabetic Agents and
Work Productivity Among Patients Having Type 2 Diabetes. J Occup Environ Med.
2011 Jan 25. 

Genovese S, Tedeschi D. Effects of Vildagliptin/Metformin Therapy on Patient-Reported Outcomes: Work Productivity, Patient Satisfaction, and Resource Utilization. Adv Ther. 2013 Feb 20. 

Krishnarajah G, DiBonaventura M, Wagner S, Gupta S.  The effect of weight changes on health-related quality of life and work impairment in patients with type 2 diabetes. Poster presentation, ISPOR 14th Annual International Meeting, Orlando, FL, May 16, 2009.

Mitchell BD, Vietri J, Zagar A, Curtis B, Reaney M. Hypoglycaemic events in patients with type 2 diabetes in the United Kingdom: associations with patient-reported outcomes and self-reported HbA1c. BMC Endocr Disord. 2013 Dec 19;13(1):59.

Pollack, M, Bolge SC, Williams S, Waterman F. The association between patient-reported diabetes symptoms and tolerability issues of oral antidiabetic agents on work and life productivity.  Poster presentation, ISPOR 14th Annual International Meeting, Orlando, FL, May 16, 2009.

Rodbard HW, Fox KM, Grandy S; Shield Study Group. Impact of obesity on work
productivity and role disability in individuals with and at risk for diabetes mellitus. Am J Health Promot. 2009;23(5):353-60.

Sadosky A, Schaefer C, Mann R, Bergstrom F, Baik R, Parsons B, Nalamachu S,
Nieshoff E, Stacey BR, Anschel A, Tuchman M. Burden of illness associated with
painful diabetic peripheral neuropathy among adults seeking treatment in the US:
results from a retrospective chart review and cross-sectional survey. Diabetes
Metab Syndr Obes. 2013;6:79-92.

Dyspepsia
Bytzer P, Langkilde LK, Christensen E, Meineche-Schmidt V. Work productivity
improvement after acid suppression in patients with uninvestigated dyspepsia. Dan
Med J. 2012 Jul;59(7):A4461.

Chey WD, Howden CW, Tack J, Ligozio G, Earnest DL. Long-Term Tegaserod Treatment for Dysmotility-like Functional Dyspepsia: Results of Two Identical 1-year Cohort Studies.  Dig Dis Sci. 2009 Dec 3. 

Kinoshita Y, Dibonaventura M, Rossi B, Iwamoto K, Wang EC, Briere JB. Burden of comorbidities among Japanese patients with atrial fibrillation: a case study of dyspepsia. Clin Exp Gastroenterol. 2013 May 20;6:51-9.

Lamori JC, Mody SH, Gross HJ, Dibonaventura MD, Patel A, Schein J, Nelson WW. 
Dyspepsia and disease burden among patients with atrial fibrillation. Crit Pathw Cardiol. 2012 Mar;11(1):14-9. 

Sander GB, Mazzoleni LE, Francesconi CF, Balbinotto G, Mazzoleni F, Wortmann AC, Cardoso Ide Q, Klamt AL, Milbradt TC; Helicobacter Eradication Relief of Dyspetic Symptoms Trial Investigators. Influence of Organic and Functional Dyspepsia on Work Productivity: The HEROES-DIP Study. Value Health. 2011 Jul-Aug;14(5 Suppl 1):S126-9. 

Veldhuyzen van Zanten S, Wahlqvist P, Talley NJ, Halling K, Vakil N, Lauritsen K, Flook N, Persson T, Bolling-Sternevald E; on behalf of the STARS II Investigators. Randomised clinical trial: the burden of illness of uninvestigated dyspepsia before and after treatment with esomeprazole - results from the STARS II study. Aliment Pharmacol Ther. 2011 Aug 17. 
Fernandez HH, Jankovic J, Holds JB, Lin D, Burns J, Verma A, Sethi K, Pappert EJ. Observational Study of IncobotulinumtoxinA for Cervical Dystonia or Blepharospasm (XCiDaBLE): Interim Results for the First 170 Subjects with Blepharospasm. Tremor Other Hyperkinet Mov (N Y). 2014 Jul 16;4:238.

Patel VD, Watanabe JH, Strauss JA, Dubey AT. Work productivity loss in
patients with dry eye disease: an online survey. Curr Med Res Opin. 2011 Mar 21.

Sindt CW, Foulks GN. Efficacy of an artificial tear emulsion in patients with dry eye associated with meibomian gland dysfunction. Clin Ophthalmol. 2013;7:1713-22.
Eye Disease
Jannini EA, Sternbach N, Limoncin E, Ciocca G, Tripodi F et al. Health-related Characteristics and Unmet Needs of Men with Erectile Dysfunction: A survey in Five European Countries. J Sex Med. 2013 Dec 9.
Erectile Dysfunction